Turning a new page on nucleostemin and self-renewal
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چکیده
منابع مشابه
Turning a new page on nucleostemin and self-renewal.
A quintessential trait of stem cells is embedded in their ability to self-renew without incurring DNA damage as a result of genome replication. One key self-renewal factor is the nucleolar GTP-binding protein nucleostemin (also known as guanine-nucleotide-binding protein-like 3, GNL3, in invertebrate species). Several studies have recently pointed to an unexpected role of nucleostemin in safegu...
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Nucleostemin (NS) is a nucleolar GTP-binding protein that was first identified in neural stem cells, the functions of which remain poorly understood. Here, we report that NS is required for mouse embryogenesis to reach blastulation, maintenance of embryonic stem cell (ESC) self-renewal, and mammary epithelial cell (MEC) reprogramming to induced pluripotent stem (iPS) cells. Ectopic NS also coop...
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To cite: Wu R. BMJ Qual Saf Published Online First: [please include Day Month Year] doi:10.1136/bmjqs-2015005031 In hospitals, breakdowns in communication has been found to be a major source of errors. Communication between clinicians can occur at scheduled times or rounds, through face-to-face meetings or may be facilitated through the use of communication tools such as pagers. For the latter,...
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On an evolutionary time scale, liquid ventilation is not new. Land-dwelling vertebrates derived from fish 350 million years ago, and fish continue to breathe through a liquid medium. However, the ability to sustain mammalian respiration artificially by a liquid ventilation technique is generally accredited to work in the early 1960s, where mice were kept alive breathing hyperbaric salt solution...
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Musicians have long been hampered by the challenge in turning sheet music while their hands are occupied playing an instrument. The sight of a human page turner assisting a pianist during a performance, for instance, is not uncommon. This need for a page turning solution is no less acute during practice sessions, which account for the vast majority of playing time. Despite widespread appreciati...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2014
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.154054